Nana Pearl makes these for a quick Friday lunch, and somehow they disappear faster than anything else on the table.

These low carb salami, mozzarella, and pepperoncini lettuce sandwiches are exactly the kind of thing my friend’s Nana Pearl would whip up on a Friday when everyone is circling the kitchen looking for something to munch on. They’re essentially Italian-inspired lettuce wraps: crisp romaine leaves take the place of bread, and we layer in salty salami, creamy mozzarella, and tangy pepperoncini. They come together quickly on a couple of sheet pans, which makes them perfect for feeding a small crowd, and somehow they always vanish faster than anything else on the table.
Serve these lettuce sandwiches straight from the sheet pans for that casual, family-style feel. They pair well with a simple antipasto platter—think olives, marinated artichokes, and cherry tomatoes—or a light vegetable soup. Sparkling water with lemon, a dry white wine, or an easy iced tea works nicely alongside the salty salami and bright pepperoncini. If you’re feeding heartier appetites, you can round out the meal with a simple cheese board or a bowl of mixed nuts.
Low Carb Salami Mozzarella Pepperoncini Lettuce Sandwiches
Servings: 6
Ingredients
2 large heads romaine lettuce, outer leaves separated and washed, well dried
8 oz sliced salami (Genoa or your favorite style)
8 oz fresh mozzarella, sliced or cut into small rectangles
1 cup sliced pepperoncini, drained
2 tbsp pepperoncini brine (from the jar)
3 tbsp extra-virgin olive oil
1 tsp Dijon mustard
1/2 tsp dried Italian seasoning or dried oregano
1/4 tsp garlic powder
1/4 tsp kosher salt, plus more to taste
1/4 tsp freshly ground black pepper
1/4 cup finely grated Parmesan cheese (optional, for sprinkling)
1/4 cup thinly sliced red onion (optional, for extra bite)
Directions
Prepare the romaine: Trim the base of each romaine head just enough to separate the larger, cup-shaped outer leaves. Choose leaves that are about hand-sized and not torn; these will act as your “bread.” Pat them very dry with a clean towel so they don’t water down the fillings.
Arrange on sheet pans: Lay the romaine leaves in a single layer, cupped side up, on two sheet pans. Overlapping a little is fine, but try to keep each leaf visible so you can build individual sandwiches quickly.
Make the quick dressing: In a small bowl, whisk together the olive oil, pepperoncini brine, Dijon mustard, Italian seasoning or oregano, garlic powder, salt, and black pepper until emulsified. Taste and adjust seasoning, adding a pinch more salt or brine if you like extra tang.

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